Clone Number: DEC-205
Description: Recombinant monoclonal antibody to CD205. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody DEC-205.
UniProt Accession Number of Target Protein: Q60767
Alternative Name(s) of Target: DEC205; DEC-205; Lymphocyte antigen 75; Ly-75; scFv DEC-205 Immunogen: This scFv was raised against the DEC-205 receptor.
Specificity: This scFv is specific for DEC-205, an endocytic receptor of dendritic cells.
Application Notes: This scFv, when fused to domain III of the Dengue virus envelope protein, is under investigation as a potential Dengue virus vaccine; fusion to the scFv targets the antigen to dendritic cells, inducing potent T cell and humoral immune responses to Dengue virus in mice (Coconi-Linares et al, 2013).
Antibody First Published in:
Coconi-Linares et al. Targeting of envelope domain III protein of DENV type 2 to DEC-205 receptor elicits neutralizing antibodies in mice. Vaccine. 2013 May 1;31(19):2366-71. PMID:23499580 Note on publication: Describes the use of this scFv to deliver a Dengue virus antigen to dendritic cells, eliciting a potent immune response. Reviews: No reviews available for this antibody yet. Be the first to submit a review at pAbmAbs and enter into their monthly prize draw.
Description: Recombinant monoclonal antibody to CD205. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody DEC-205.
UniProt Accession Number of Target Protein: Q60767
Alternative Name(s) of Target: DEC205; DEC-205; Lymphocyte antigen 75; Ly-75; scFv DEC-205 Immunogen: This scFv was raised against the DEC-205 receptor.
Specificity: This scFv is specific for DEC-205, an endocytic receptor of dendritic cells.
Application Notes: This scFv, when fused to domain III of the Dengue virus envelope protein, is under investigation as a potential Dengue virus vaccine; fusion to the scFv targets the antigen to dendritic cells, inducing potent T cell and humoral immune responses to Dengue virus in mice (Coconi-Linares et al, 2013).
Antibody First Published in:
Coconi-Linares et al. Targeting of envelope domain III protein of DENV type 2 to DEC-205 receptor elicits neutralizing antibodies in mice. Vaccine. 2013 May 1;31(19):2366-71. PMID:23499580 Note on publication: Describes the use of this scFv to deliver a Dengue virus antigen to dendritic cells, eliciting a potent immune response. Reviews: No reviews available for this antibody yet. Be the first to submit a review at pAbmAbs and enter into their monthly prize draw.
Published Application(s): vaccination
Published Species Reactivity:
Published Species Reactivity:
Mouse
Tags: Virology, antigen presentation, vaccination
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