Clone Number: OX-26
Description: Recombinant monoclonal antibody to CD71. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma OX-26.
UniProt Accession Number of Target Protein: Q99376
Alternative Name(s) of Target: transferrin receptor; TfR; p90; T9; TFR1; OX26; MRC OX26; MRC OX-26 Immunogen: OX-26 was prepared by immunizing BALB/c mice with rat transferrin receptor.
Specificity: OX-101 binds specifically to CD47 and has been shown to compete with OX-41 for binding . CD47 acts as an adhesionn receptor for THBS1 on platelets and is involved in the modulation of integrins (signalling). Acts as a SIRPA receptor - SIRPA binding prevents maturation of immature dentritic cells and and inhibits cytokine production by mature dendritic cells. Possibly involved in changes to membrane permeability due to virus infection.
Application Notes: This antibody can be used for affinity chromatography purification and can block the interaction between OX41-CD4d3+4 beads and cells.
Antibody First Published in:
Vernon-Wilson et al CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPalpha 1. Eur J Immunol 30:2130-7 2000 PMID:9712053 Note on publication: Describes the use of OX-101 in identifying CD47 as the ligand for SIRP. Reviews: No reviews available for this antibody yet. Be the first to submit a review at pAbmAbs and enter into their monthly prize draw.
Description: Recombinant monoclonal antibody to CD71. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma OX-26.
UniProt Accession Number of Target Protein: Q99376
Alternative Name(s) of Target: transferrin receptor; TfR; p90; T9; TFR1; OX26; MRC OX26; MRC OX-26 Immunogen: OX-26 was prepared by immunizing BALB/c mice with rat transferrin receptor.
Specificity: OX-101 binds specifically to CD47 and has been shown to compete with OX-41 for binding . CD47 acts as an adhesionn receptor for THBS1 on platelets and is involved in the modulation of integrins (signalling). Acts as a SIRPA receptor - SIRPA binding prevents maturation of immature dentritic cells and and inhibits cytokine production by mature dendritic cells. Possibly involved in changes to membrane permeability due to virus infection.
Application Notes: This antibody can be used for affinity chromatography purification and can block the interaction between OX41-CD4d3+4 beads and cells.
Antibody First Published in:
Vernon-Wilson et al CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPalpha 1. Eur J Immunol 30:2130-7 2000 PMID:9712053 Note on publication: Describes the use of OX-101 in identifying CD47 as the ligand for SIRP. Reviews: No reviews available for this antibody yet. Be the first to submit a review at pAbmAbs and enter into their monthly prize draw.
Published Application(s): IP; FC; WB; block
Published Species Reactivity:
Published Species Reactivity:
Rat
Tags: CD markers, Cell-type markers, adhesion, cancer, immunology, tumour immunology
Products Available based on this clone
| Product | Expected Species Reactivity | Isotype/Format | Modification | Products | Intro Price | Availability |
|---|---|---|---|---|---|---|
| Ab00558-2.0 Anti-CD71 [OX-26] | Rat | Mouse IgG2a | 200 µg: | Ships in 2-3 weeks | ||
| Ab00558-8.1 Anti-CD71 [OX-26] | Rat | Rat IgG2b | 200 µg: | Ships in 2-3 weeks | ||
| Ab00558-23.0 Anti-CD71 [OX-26] | Rat | Rabbit IgG | 200 µg: | In stock | ||
| Ab00558-8.4 Anti-CD71 [OX-26] | Rat | Rat IgG2b | Fc Silent™ | 200 µg: | Ships in 2-3 weeks | |
| Ab00558-2.3 Anti-CD71 [OX-26] | Rat | Mouse IgG2a | Fc Silent™ | 200 µg: | Ships in 2-3 weeks |
If you are interested in bulk prices or cannot find a particular product based on this clone, please contact sales@absoluteantibody.com and we will do our best to help you.
