Anti-CD90 [T11D7e]

Clone Number: T11D7e
Description: Recombinant monoclonal antibody to CD90. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma T11D7e. Developed in partnership with Ximbio (www.ximbio.com).
UniProt Accession Number of Target Protein: P01830
Alternative Name(s) of Target: P01831; Thy1.1; Thy-1 membrane glycoprotein; Thy1; Thy-1 antigen Immunogen: This antibody was raised by immunising CBA mice with xenogeneic rat thymocytes, which express the Thy-1.1 antigen.
Specificity: This antibody binds murine and rat CD90. While CD90 is a monomorphic determinant in rats, CD90 is polymorphic in mice. As a result, this antibody reacts with Thy1.1-expressing mice, including AKR and FVB mice, but not Thy1.2-expressing mice, such as CBA and BALB/c. 
Application Notes: This antibody has been used in indirect immunofluorescence analysis of Thy-1 antigen expression in both methanol-fixed and living cell cultures (Dulbecco et al, 1979; Hasthorpe, 1980). This antibody has also been used, in conjunction with rabbit complement, to deplete Thy1-expressing fibroblasts from serum samples through complement-mediated lysis (Mahanthappa et al, 1996).
Antibody First Published in:
Lake et al. Production and characterization of cytotoxic Thy-1 antibody-secreting hybrid cell lines. Detection of T cell subsets. Eur J Immunol. 1979 Nov;9(11):875-86. PMID:393521 Note on publication: Describes the original generation of this antibody as part of a panel of anti-Thy1.1 mAbs. Reviews: No reviews available for this antibody yet. Be the first to submit a review at pAbmAbs and enter into their monthly prize draw.