Anti-DCIR [9E8]

Clone Number: 9E8
Description: Recombinant monoclonal antibody to DCIR. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 9E8.
UniProt Accession Number of Target Protein: Q9UMR7 
Alternative Name(s) of Target: CD367; Clec4A; C-type lectin domain family 4 member A; LLIR; CLECSF6; C-type lectin DDB27; C-type lectin superfamily member 6; Dendritic cell immunoreceptor; Lectin-like immunoreceptor Immunogen: This antibody was raised by immunising BALB/c mice with a dendritic cell immunoreceptor ectodomain-human Fc fusion protein.
Specificity: This antibody is specific for human DCIR, which is expressed by monocytes, B cells, neutrophils, granulocytes and dendritic cells.
Application Notes: This antibody has been used in flow cytometric analysis of DCIR expression by peripheral blood mononuclear cells (Klechevsky et al, 2010). A recombinant humanised form of this antibody fused to protein antigens is under investigation as an antigen-targeting vaccine (Flamar et al, 2012), and has been shown to trigger antigen-specific CD8+ T cell immunity.
Antibody First Published in:
Klechevsky et al. Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR Blood. 2010 Sep 9; 116(10): 1685–1697. Note on publication: Describes the original generation of this antibody, and preliminary investigation into its use as an antigen-targeting vaccine. Reviews: No reviews available for this antibody yet. Be the first to submit a review at pAbmAbs and enter into their monthly prize draw.