Clone Number: 9E8
Description: Recombinant monoclonal antibody to DCIR. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 9E8.
UniProt Accession Number of Target Protein: Q9UMR7
Alternative Name(s) of Target: CD367; Clec4A; C-type lectin domain family 4 member A; LLIR; CLECSF6; C-type lectin DDB27; C-type lectin superfamily member 6; Dendritic cell immunoreceptor; Lectin-like immunoreceptor Immunogen: This antibody was raised by immunising BALB/c mice with a dendritic cell immunoreceptor ectodomain-human Fc fusion protein.
Specificity: This antibody is specific for human DCIR, which is expressed by monocytes, B cells, neutrophils, granulocytes and dendritic cells.
Application Notes: This antibody has been used in flow cytometric analysis of DCIR expression by peripheral blood mononuclear cells (Klechevsky et al, 2010). A recombinant humanised form of this antibody fused to protein antigens is under investigation as an antigen-targeting vaccine (Flamar et al, 2012), and has been shown to trigger antigen-specific CD8+ T cell immunity.
Antibody First Published in:
Klechevsky et al. Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR Blood. 2010 Sep 9; 116(10): 1685–1697. Note on publication: Describes the original generation of this antibody, and preliminary investigation into its use as an antigen-targeting vaccine. Reviews: No reviews available for this antibody yet. Be the first to submit a review at pAbmAbs and enter into their monthly prize draw.
Description: Recombinant monoclonal antibody to DCIR. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 9E8.
UniProt Accession Number of Target Protein: Q9UMR7
Alternative Name(s) of Target: CD367; Clec4A; C-type lectin domain family 4 member A; LLIR; CLECSF6; C-type lectin DDB27; C-type lectin superfamily member 6; Dendritic cell immunoreceptor; Lectin-like immunoreceptor Immunogen: This antibody was raised by immunising BALB/c mice with a dendritic cell immunoreceptor ectodomain-human Fc fusion protein.
Specificity: This antibody is specific for human DCIR, which is expressed by monocytes, B cells, neutrophils, granulocytes and dendritic cells.
Application Notes: This antibody has been used in flow cytometric analysis of DCIR expression by peripheral blood mononuclear cells (Klechevsky et al, 2010). A recombinant humanised form of this antibody fused to protein antigens is under investigation as an antigen-targeting vaccine (Flamar et al, 2012), and has been shown to trigger antigen-specific CD8+ T cell immunity.
Antibody First Published in:
Klechevsky et al. Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR Blood. 2010 Sep 9; 116(10): 1685–1697. Note on publication: Describes the original generation of this antibody, and preliminary investigation into its use as an antigen-targeting vaccine. Reviews: No reviews available for this antibody yet. Be the first to submit a review at pAbmAbs and enter into their monthly prize draw.
Published Application(s): FC
Published Species Reactivity:
Published Species Reactivity:
Human
Tags: CD markers, adaptive immunity, antigen presentation
Products Available based on this clone
Product | Expected Species Reactivity | Isotype/Format | Modification | Products | Intro Price | Availability |
---|---|---|---|---|---|---|
Ab00911-1.1 Anti-DCIR [9E8] | Human | Mouse IgG1 | 200 µg: | Ships in 2-3 weeks | ||
Ab00911-10.0 Anti-DCIR [9E8] | Human | Human IgG1 | 200 µg: | Ships in 2-3 weeks | ||
Ab00911-23.0 Anti-DCIR [9E8] | Human | Rabbit IgG | 200 µg: | Ships in 2-3 weeks | ||
Ab00911-13.12 Anti-DCIR [9E8] | Human | Human IgG4-P | 200 µg: | Ships in 2-3 weeks | ||
Ab00911-10.3 Anti-DCIR [9E8] | Human | Human IgG1 | Fc Silent™ | 200 µg: | Ships in 2-3 weeks |
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