Description: Recombinant monoclonal antibody to DC-SIGNR. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 16E7.
Species and Isotype: Rabbit IgG, kappa
Clone Number: 16E7
UniProt Accession Number of Target Protein: Q9H2X3
Alternative Name(s) of Target: CD299; C-type lectin domain family 4 member M; CD209 antigen-like protein 1; DC-SIGN-related protein; CLEC4M; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; DC-SIGN2; Liver/lymph node-specific ICAM-3-grabbing non-integrin; L-SIGN
Published Application(s): FC; IHC
Published Species Reactivity: Human
Immunogen: CD299
Specificity: Human CD299, which is an oligomeric type II transmembrane protein with a C-type lectin extracellular domain, the expression of which is restricted to immature DC, macrophages in the lung, and endothelial cells in the liver. It binds ICAM-3 and ICAM-7 to mediate the interaction of DC with T lymphocytes and endothelial cells in the initial stages of immune response and in the migratory behavior of DC. CD299 also binds the gp120 protein of HIV and the E2 envelope protein of HCV, thereby playing a role in viral infection.

Product Form

Purification: Protein A affinity purified
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Concentration: See vial label.