Ab00130-23.0 Anti-DC-SIGNR [16E7]
Description: Recombinant monoclonal antibody to DC-SIGNR. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 16E7.
Clone Number: 16E7
UniProt Accession Number of Target Protein: Q9H2X3
Alternative Name(s) of Target: CD299; C-type lectin domain family 4 member M; CD209 antigen-like protein 1; DC-SIGN-related protein; CLEC4M; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; DC-SIGN2; Liver/lymph node-specific ICAM-3-grabbing non-integrin; L-SIGN
Published Application(s): FC; IHC
Published Species Reactivity: Human
Immunogen: CD299
Specificity: Human CD299, which is an oligomeric type II transmembrane protein with a C-type lectin extracellular domain, the expression of which is restricted to immature DC, macrophages in the lung, and endothelial cells in the liver. It binds ICAM-3 and ICAM-7 to mediate the interaction of DC with T lymphocytes and endothelial cells in the initial stages of immune response and in the migratory behavior of DC. CD299 also binds the gp120 protein of HIV and the E2 envelope protein of HCV, thereby playing a role in viral infection.
Supplied in: PBS with preservative (0.02% Proclin 300)
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Concentration: See vial label.
This chimeric rabbit antibody was made using the variable domain sequences of the original murine IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Species and Isotype: Rabbit IgG, kappaClone Number: 16E7
UniProt Accession Number of Target Protein: Q9H2X3
Alternative Name(s) of Target: CD299; C-type lectin domain family 4 member M; CD209 antigen-like protein 1; DC-SIGN-related protein; CLEC4M; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; DC-SIGN2; Liver/lymph node-specific ICAM-3-grabbing non-integrin; L-SIGN
Published Application(s): FC; IHC
Published Species Reactivity: Human
Immunogen: CD299
Specificity: Human CD299, which is an oligomeric type II transmembrane protein with a C-type lectin extracellular domain, the expression of which is restricted to immature DC, macrophages in the lung, and endothelial cells in the liver. It binds ICAM-3 and ICAM-7 to mediate the interaction of DC with T lymphocytes and endothelial cells in the initial stages of immune response and in the migratory behavior of DC. CD299 also binds the gp120 protein of HIV and the E2 envelope protein of HCV, thereby playing a role in viral infection.
Product Form
Purification: Protein A affinity purifiedSupplied in: PBS with preservative (0.02% Proclin 300)
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Concentration: See vial label.
Important note – This product is for research use only. It is not intended for use in therapeutic or diagnostic
procedures for humans or animals.
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