Description: Recombinant monoclonal antibody to CD38. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma AT13/5.
Species and Isotype: Mouse IgG1, kappa
Clone Number: AT13/5
UniProt Accession Number of Target Protein:
Published Application(s): FC
Published Species Reactivity: Human
Immunogen: Namalwa cells emulsified in CFA.
Specificity: Binds specifically to human CD38, an approximately 45 kDa type II transmembrane protein, expressed on essentially all pre-B lymphocytes, plasma cells, and thymocytes. Also present on activated T lymphocytes, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. Bimodally expressed during B cell development, modulating from high in immature cells to low in intermediate ones and back to high on mature B cells. This antibody competes with clone HB7 (Ab00128) (Ellis 1995) which has been shon to bind to an epitope between amino acids 273-285).
Application Notes: The antibody binds to CD38, a glycoportein on the surface of various immune cells that catalyzes the hydrolysis of cyclic ADP-ribose to NAD+ and ADP-ribose.
Antibody First Published in:
Ellis et al Engineered anti-CD38 monoclonal antibdies for immunotherapy of multiple myeloma. Journal of Immunology PMID:7608568 Note on publication: Describes the generation of murine monoclonal antibodies against CD38 and its potential use in therapy of multiple myeloma.

Product Form

Purification: Protein A affinity purified
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Concentration: See vial label.