Ab00366-10.3 Anti-Neurotoxin AahII [4C1]
Description: Recombinant monoclonal antibody to Neurotoxin AahII. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the scFv 4C1. This antibody was created using our proprietary Fc Silent™ engineered Fc domain containing key point mutations that abrogate binding to Fc gamma receptors.
Clone Number: 4C1
UniProt Accession Number of Target Protein: P01484
Alternative Name(s) of Target: neurotoxin II, alpha-mammal toxin II
Published Application(s): ELISA; NTRL
Published Species Reactivity: Androctonus australis hector
Immunogen: C-terminus of AahII
Specificity: This scFv binds specifically to the C-terminal region of the toxin.
Application Notes: This scFv binds to the C-terminus of the neurotoxin AahII, which binds and blocks sodium channels in a voltage-independent manner. The antibody neutralizes the toxin.
Antibody First Published in:
Mousli et al. 1999 A recombinant single-chain antibody fragment that neutralizes toxin II from the venom of the scorpion Androctonus australis hector. FEBS Letters 1999; 442(2-3):183-188 PMID:9928998 Note on publication: Describes the engineering of an scFv that, similar to the whole antibody, neutralizes the activity of the neurotoxin.
Concentration: See vial label.
This chimeric human antibody was made using the variable domain sequences of the original mouse scFv format for improved compatibility with existing reagents, assays and techniques.
Species and Isotype: Human IgG1, Fc Silent™, kappaClone Number: 4C1
UniProt Accession Number of Target Protein: P01484
Alternative Name(s) of Target: neurotoxin II, alpha-mammal toxin II
Published Application(s): ELISA; NTRL
Published Species Reactivity: Androctonus australis hector
Immunogen: C-terminus of AahII
Specificity: This scFv binds specifically to the C-terminal region of the toxin.
Application Notes: This scFv binds to the C-terminus of the neurotoxin AahII, which binds and blocks sodium channels in a voltage-independent manner. The antibody neutralizes the toxin.
Antibody First Published in:
Mousli et al. 1999 A recombinant single-chain antibody fragment that neutralizes toxin II from the venom of the scorpion Androctonus australis hector. FEBS Letters 1999; 442(2-3):183-188 PMID:9928998 Note on publication: Describes the engineering of an scFv that, similar to the whole antibody, neutralizes the activity of the neurotoxin.
Product Form
Purification: Protein A affinity purified Supplied in: Bulk size: PBS only. Standard size: PBS with 0.02% Proclin 300.
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°CConcentration: See vial label.
Important note – This product is for research use only. It is not intended for use in therapeutic or diagnostic
procedures for humans or animals.
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