Description: Recombinant monoclonal antibody to Neurotoxin AahII. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the scFv 4C1. This antibody was created using our proprietary Fc Silent™ engineered Fc domain containing key point mutations that abrogate binding of Fc Receptor and complement.
Species and Isotype: Human IgG1, Fc Silent™, kappa
Clone Number: 4C1
UniProt Accession Number of Target Protein: P01484
Alternative Name(s) of Target: neurotoxin II, alpha-mammal toxin II
Published Application(s): ELISA; NTRL
Published Species Reactivity: Androctonus australis hector
Immunogen: C-terminus of AahII
Specificity: This scFv binds specifically to the C-terminal region of the toxin.
Application Notes: This scFv binds to the C-terminus of the neurotoxin AahII, which binds and blocks sodium channels in a voltage-independent manner. The antibody neutralizes the toxin.
Antibody First Published in:
Mousli et al. 1999 A recombinant single-chain antibody fragment that neutralizes toxin II from the venom of the scorpion Androctonus australis hector. FEBS Letters 1999; 442(2-3):183-188 PMID:9928998 Note on publication: Describes the engineering of an scFv that, similar to the whole antibody, neutralizes the activity of the neurotoxin.

Product Form

Purification: Protein A affinity purified
Supplied in: PBS with preservative (0.02% Proclin 300)
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Concentration: See vial label.