Ab00421-10.3 Anti-Type IV collagenase [3G11]
Description: Recombinant monoclonal antibody to Type IV collagenase. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 3G11. This antibody was created using our proprietary Fc Silent™ engineered Fc domain containing key point mutations that abrogate binding to Fc gamma receptors.
Clone Number: 3G11
UniProt Accession Number of Target Protein: P08253
Alternative Name(s) of Target: MMP2; Matrix Metalloprotease 2
Published Application(s): ELISA
Published Species Reactivity: Human
Immunogen: Recombinant human type IV collagenase.
Specificity: This antibody binds specifically to human type IV collagenase and does not show any cross-reactivity with any other collagenases.
Application Notes: This antibody binds to human type IV collagenase, a metalloproteinase involved in degrading matrix proteins and hence contributing largely to metastasis in various types of cancer.
Antibody First Published in:
Li et al. Antitumor activity of anti-type IV collagenase monoclonal antibody and its lidamycin conjugate against colon carcinoma. World Journal of Gastroenterology 2007; 11(29):4478-4483 PMID:16052675 Note on publication: Describes the generation of a mouse monoclonal antibody against type IV collagenase in order to study possible routes towards colon carcinoma treatment.
Concentration: See vial label.
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Species and Isotype: Human IgG1, Fc Silent™, kappaClone Number: 3G11
UniProt Accession Number of Target Protein: P08253
Alternative Name(s) of Target: MMP2; Matrix Metalloprotease 2
Published Application(s): ELISA
Published Species Reactivity: Human
Immunogen: Recombinant human type IV collagenase.
Specificity: This antibody binds specifically to human type IV collagenase and does not show any cross-reactivity with any other collagenases.
Application Notes: This antibody binds to human type IV collagenase, a metalloproteinase involved in degrading matrix proteins and hence contributing largely to metastasis in various types of cancer.
Antibody First Published in:
Li et al. Antitumor activity of anti-type IV collagenase monoclonal antibody and its lidamycin conjugate against colon carcinoma. World Journal of Gastroenterology 2007; 11(29):4478-4483 PMID:16052675 Note on publication: Describes the generation of a mouse monoclonal antibody against type IV collagenase in order to study possible routes towards colon carcinoma treatment.
Product Form
Purification: Protein A affinity purified Supplied in: Bulk size: PBS only. Standard size: PBS with 0.02% Proclin 300.
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°CConcentration: See vial label.
Important note – This product is for research use only. It is not intended for use in therapeutic or diagnostic
procedures for humans or animals.
2019