Description: Recombinant monoclonal antibody to Type IV collagenase. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 3G11. This antibody was created using our proprietary Fc Silent™ engineered Fc domain containing key point mutations that abrogate binding of Fc Receptor and complement.
Species and Isotype: Human IgG1, Fc Silent™, kappa
Clone Number: 3G11
UniProt Accession Number of Target Protein: P08253
Alternative Name(s) of Target: MMP2; Matrix Metalloprotease 2
Published Application(s): ELISA
Published Species Reactivity: Human
Immunogen: Recombinant human type IV collagenase.
Specificity: This antibody binds specifically to human type IV collagenase and does not show any cross-reactivity with any other collagenases.
Application Notes: This antibody binds to human type IV collagenase, a metalloproteinase involved in degrading matrix proteins and hence contributing largely to metastasis in various types of cancer.
Antibody First Published in:
Li et al. Antitumor activity of anti-type IV collagenase monoclonal antibody and its lidamycin conjugate against colon carcinoma. World Journal of Gastroenterology 2007; 11(29):4478-4483 PMID:16052675 Note on publication: Describes the generation of a mouse monoclonal antibody against type IV collagenase in order to study possible routes towards colon carcinoma treatment.

Product Form

Purification: Protein A affinity purified
Supplied in: PBS with preservative (0.02% Proclin 300)
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Concentration: See vial label.