Ab00522-10.6 Anti-Galanin [5B4]
Description: Recombinant monoclonal antibody to Galanin . Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 5B4. This is a Fab fragment with a his-tag.
Clone Number: 5B4
UniProt Accession Number of Target Protein: P22466
Alternative Name(s) of Target: Galanin peptide
Published Application(s): ELISA; WB; ICC; Block
Published Species Reactivity: Human, Mouse
Immunogen: C-terminal fusions of KLH to human galanin,
Specificity: The antibody binds to galanin with an affinity constant (Kd) of 0.13 nM.
Application Notes: The antibody binds specifically to galanin, a neuropeptide involved in many biological processes, including nociception, modulation and inhibition of action potentials, cognition, feeding, regulation of mood and blood pressure, smooth muscle contraction of the gastrointestinal (GI) tract and insulin release. Galanin acts on three G-protein coupled receptors, GALR1, GALR2 and GALR3, which are highly expressed in the brain, spinal cord and GI tract of humans and other mammals. Activation of the receptors has been reported to activate ATP-sensitive K+ channels, and inhibit voltage-gated Ca2+ channels. Galanin has been associated with the development of cancer, Alzheimer's disease, epilepsy, depression, eating disorders, diabetes and obesity. The monoclonal antibody 5B4 binds to the C-terminal region of Galanin, between residues 21 and 27, blocking its activity, and can be used clinically in the prevention and treatment of diseases mentioned.
Concentration: See vial label.
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Species and Isotype: Human Fab fragment, His-Tagged, kappaClone Number: 5B4
UniProt Accession Number of Target Protein: P22466
Alternative Name(s) of Target: Galanin peptide
Published Application(s): ELISA; WB; ICC; Block
Published Species Reactivity: Human, Mouse
Immunogen: C-terminal fusions of KLH to human galanin,
Specificity: The antibody binds to galanin with an affinity constant (Kd) of 0.13 nM.
Application Notes: The antibody binds specifically to galanin, a neuropeptide involved in many biological processes, including nociception, modulation and inhibition of action potentials, cognition, feeding, regulation of mood and blood pressure, smooth muscle contraction of the gastrointestinal (GI) tract and insulin release. Galanin acts on three G-protein coupled receptors, GALR1, GALR2 and GALR3, which are highly expressed in the brain, spinal cord and GI tract of humans and other mammals. Activation of the receptors has been reported to activate ATP-sensitive K+ channels, and inhibit voltage-gated Ca2+ channels. Galanin has been associated with the development of cancer, Alzheimer's disease, epilepsy, depression, eating disorders, diabetes and obesity. The monoclonal antibody 5B4 binds to the C-terminal region of Galanin, between residues 21 and 27, blocking its activity, and can be used clinically in the prevention and treatment of diseases mentioned.
Product Form
Purification: Purified by Immobilized Metal Affinity Chromatography Supplied in: Bulk size: PBS only. Standard size: PBS with 0.02% Proclin 300.
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°CConcentration: See vial label.
Product Code: Ab00522-10.6
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Human Fab fragment
His-Tagged
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Important note – This product is for research use only. It is not intended for use in therapeutic or diagnostic
procedures for humans or animals.
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