Description: Recombinant monoclonal antibody to Galanin . Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 4B3. This antibody was created using our proprietary Fc Silent™ engineered Fc domain containing key point mutations that abrogate binding of Fc Receptor and complement.
Species and Isotype: Mouse IgG2a, Fc Silent™, kappa
Clone Number: 4B3
UniProt Accession Number of Target Protein: P22466
Alternative Name(s) of Target: Galanin peptide
Published Application(s): ELISA; WB; ICC; Block
Published Species Reactivity: Human, Mouse
Immunogen: C-terminal fusions of KLH to human galanin,
Specificity: The antibody binds to galanin with an affinity constant (Kd) of 0.07 nM reported for the original antibody.
Application Notes: The antibody binds specifically to galanin, a neuropeptide involved in many biological processes, including nociception, modulation and inhibition of action potentials, cognition, feeding, regulation of mood and blood pressure, smooth muscle contraction of the gastrointestinal (GI) tract and insulin release. Galanin acts on three G-protein coupled receptors, GALR1, GALR2 and GALR3, which are highly expressed in the brain, spinal cord and GI tract of humans and other mammals. Activation of the receptors has been reported to activate ATP-sensitive K+ channels, and inhibit voltage-gated Ca2+ channels. Galanin has been associated with the development of cancer, Alzheimer's disease, epilepsy, depression, eating disorders, diabetes and obesity. The monoclonal antibody 4B3 binds to the C-terminal region of Galanin, between residues 21 and 27, blocking its activity, and can be used clinically in the prevention and treatment of diseases mentioned.

Product Form

Purification: Protein A affinity purified
Supplied in: PBS with preservative (0.02% Proclin 300)
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Concentration: See vial label.