Description: Recombinant monoclonal antibody to Basigin. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma Ab-1. This is a Fab fragment with a his-tag.
Species and Isotype: Human Fab fragment, His-Tagged, kappa
Clone Number: Ab-1
UniProt Accession Number of Target Protein: P35613
Alternative Name(s) of Target: BSG; CD147; Cluster of differentiation 147; Extracellular matrix metalloproteinase inducer; EMMPRIN; 5F7; Collagenase stimulatory factor; Leukocyte activation antigen M6; Tumor cell-derived collagenase stimulatory factor; TCSF
Published Application(s): ELISA; Block
Published Species Reactivity: Human
Immunogen: Recombinant ectodomains of human basigin.
Specificity: The antibody binds to basigin with an affinity (Kd) of 4 nM reported for the original antibody.
Application Notes: The antibody binds specifically to basigin, a protein of the immunoglobulin superfamily which is expressed on the surface of erythrocyte and acts as a receptor for the human malaria parasite P. falciparum. The recombinant chimeric monoclonal antibody Ab-1 acts by blocking the interaction between basigin and PfRH5, a ligand necessary for the P. falciparum erythrocyte invasion, thereby inhibiting the development of malaria.
Antibody First Published in:
Zenonos ZA, Dummler SK, Müller-Sienerth N, Chen J, Preiser PR, Rayner JC, Wright GJ. Basigin is a druggable target for host-oriented antimalarial interventions. J Exp Med. 2015 Jul 27;212(8):1145-51. PMID:26195724 Note on publication: Describes the development of the recombinant chimeric antibody Ab-1 directed against basigin, an erythrocyte receptor involved in parasite invasion.

Product Form

Purification: Purified by Immobilized Metal Affinity Chromatography
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Concentration: See vial label.