Ab00665-23.0 Anti-Bet v 1 [BAB2]
Description: Recombinant monoclonal antibody to Bet v 1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the B-cell line BAB2.
Clone Number: BAB2
UniProt Accession Number of Target Protein: P15494
Alternative Name(s) of Target: Major Allergen from Birch Pollen; BETVIA
Published Application(s): ELISA; activate; WB
Published Species Reactivity: Birch (Betula pendula)
Immunogen: Bet v 1, a major allergen of the European white birch.
Specificity: This antibody binds to Bet v 1. It recognises amino acids 1-74 of recombinant Bet v 1 by Western Blot, whilst showing no binding to AA 75-160.
Application Notes: This antibody binds to Bet v 1 and appears to enhance binding of IgE as well as Bet v 1-induced immediate-type skin reactions and thus represent 'enhancing antibodies'.
Antibody First Published in:
Eibensteiner et al. Expression of a human IgG4 antibody, BAB2, with specificity for the major Birch pollen allergen, Bet v 1 in Escherichia coli: recombinant BAB2 Fabs enhance the allergic reaction. Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):190-2. PMID:10224374 Note on publication: Describes the generation and characterization of this antibody.
Concentration: See vial label.
This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.
Species and Isotype: Rabbit IgG, kappaClone Number: BAB2
UniProt Accession Number of Target Protein: P15494
Alternative Name(s) of Target: Major Allergen from Birch Pollen; BETVIA
Published Application(s): ELISA; activate; WB
Published Species Reactivity: Birch (Betula pendula)
Immunogen: Bet v 1, a major allergen of the European white birch.
Specificity: This antibody binds to Bet v 1. It recognises amino acids 1-74 of recombinant Bet v 1 by Western Blot, whilst showing no binding to AA 75-160.
Application Notes: This antibody binds to Bet v 1 and appears to enhance binding of IgE as well as Bet v 1-induced immediate-type skin reactions and thus represent 'enhancing antibodies'.
Antibody First Published in:
Eibensteiner et al. Expression of a human IgG4 antibody, BAB2, with specificity for the major Birch pollen allergen, Bet v 1 in Escherichia coli: recombinant BAB2 Fabs enhance the allergic reaction. Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):190-2. PMID:10224374 Note on publication: Describes the generation and characterization of this antibody.
Product Form
Purification: Protein A affinity purified Supplied in: Bulk size: PBS only. Standard size: PBS with 0.02% Proclin 300.
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°CConcentration: See vial label.
Important note – This product is for research use only. It is not intended for use in therapeutic or diagnostic
procedures for humans or animals.
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