Ab00671-23.0 Anti-CD45 [YTH24.5]
Description: Recombinant monoclonal antibody to CD45. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma YTH24.5.
Clone Number: YTH24.5
UniProt Accession Number of Target Protein:
Published Application(s): FC; IP; depletion; IF
Published Species Reactivity: Human
Immunogen: Human T-cells injected into DA rats.
Specificity: This antibody binds human CD45, the leukocyte common antigen, at epitope P2.
Application Notes: This antibody binds to and immunoprecipiates human CD45. In the original rat IgG2b format it was shown to trigger complement mediated lysis and synergizes with clone YTH54.12 (Ab00672) which binds a different epitope on human CD45.
Antibody First Published in:
Bidon et al. Therapeutic potential of monoclonal antibodies to the leukocyte-common antigen. Synergy and interference in complement-mediated lysis Transplantation. 1985 Nov;40(5):538-44. PMID:2414870 Note on publication: Describes generation and characterization of the synergistic effect of several anti-CD45 antibodies on lysis.
Supplied in: PBS with preservative (0.02% Proclin 300)
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Concentration: See vial label.
This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Species and Isotype: Rabbit IgG, kappaClone Number: YTH24.5
UniProt Accession Number of Target Protein:
Published Application(s): FC; IP; depletion; IF
Published Species Reactivity: Human
Immunogen: Human T-cells injected into DA rats.
Specificity: This antibody binds human CD45, the leukocyte common antigen, at epitope P2.
Application Notes: This antibody binds to and immunoprecipiates human CD45. In the original rat IgG2b format it was shown to trigger complement mediated lysis and synergizes with clone YTH54.12 (Ab00672) which binds a different epitope on human CD45.
Antibody First Published in:
Bidon et al. Therapeutic potential of monoclonal antibodies to the leukocyte-common antigen. Synergy and interference in complement-mediated lysis Transplantation. 1985 Nov;40(5):538-44. PMID:2414870 Note on publication: Describes generation and characterization of the synergistic effect of several anti-CD45 antibodies on lysis.
Product Form
Purification: Protein A affinity purifiedSupplied in: PBS with preservative (0.02% Proclin 300)
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Concentration: See vial label.
Important note – This product is for research use only. It is not intended for use in therapeutic or diagnostic
procedures for humans or animals.
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