Description: Recombinant monoclonal antibody to CD45. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma YTH24.5.
Species and Isotype: Rabbit IgG, kappa
Clone Number: YTH24.5
UniProt Accession Number of Target Protein:
Published Application(s): FC; IP; depletion; IF
Published Species Reactivity: Human
Immunogen: Human T-cells injected into DA rats.
Specificity: This antibody binds human CD45, the leukocyte common antigen, at epitope P2.
Application Notes: This antibody binds to and immunoprecipiates human CD45. In the original rat IgG2b format it was shown to trigger complement mediated lysis and synergizes with clone YTH54.12 (Ab00672) which binds a different epitope on human CD45.
Antibody First Published in:
Bidon et al. Therapeutic potential of monoclonal antibodies to the leukocyte-common antigen. Synergy and interference in complement-mediated lysis Transplantation. 1985 Nov;40(5):538-44. PMID:2414870 Note on publication: Describes generation and characterization of the synergistic effect of several anti-CD45 antibodies on lysis.

Product Form

Purification: Protein A affinity purified
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Concentration: See vial label.