United Kingdom (UK)
Recombinant monoclonal antibody to HLA Class 1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma W6/32.
UniProt Accession Number of Target Protein: O15506
Alternative Name(s) of Target: HLA A;B,C; HLA ABC
Immunogen: Human tonsil lymphocyte membranes.
Specificity: Recognizes an antigenic determinant shared among products of the HLA A, B and C loci.
Application Notes: This antibody binds to human human major histocompatibility complex class I, which is associated with beta 2-microglobulin and expressed on all human nucleated cells. It is a presents MHC class I antigens and is a central component of of cell-mediated immune response and tumor surveillance.
Antibody first published in:
Barnstable CJ, Bodmer WF, Brown G, Galfre G, Milstein C, Williams AF, Ziegler A. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis. Cell. 1978 May;14(1):9-20. PMID:667938
Note on publication:
Describes generation of panel of antibodies including this clone, W6/32.