Anti-CD4 [MT310] Standard size

Description: Recombinant monoclonal antibody to CD4. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma MT310.
Isotype and Format: Rabbit IgG, kappa
Clone Number: MT310
Published Application(s): WB; IP; IF; IHC-P; FC
Published Species Reactivity: Human; Rhesus Monkey; Cynomolgus Monkey
Immunogen:
Specificity: mt310 binds to the extracellular domain D1 of CD4 – the same site as the HIV-1 gp120-binding site
Application Notes: mt310 can inhibit gp120 binding to CD4, which blocks HIV infectivity of CD4+ T lymphocytes, as well as the binding of MHCII, which results in the block of T-cell activation, possibly leading to the induction of anergy. Antibody binding to CD4 additionally causes the induction of GM-CSF, TNF-α (only after 20?h) and IL-10.
Antibody First Published in:
Herzog et al. Lancet. 1987 Dec 19;2(8573):1461-2. PMID:2892019 Note on publication: Describes the use of this antibody in immunosuppression.

Product Form

This is a Standard size product. Purified antibody.
Purification: Protein A affinity purified
Supplied in: PBS with 0.02% Proclin 300.
Storage Recommendation: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Concentration: See vial label

Product Code: Ab00217-23.0

Rabbit IgG

In stock
Standard size 200 µg
Custom conjugation:
Clear selection