United Kingdom (UK)
Recombinant monoclonal antibody to CD35 (complement receptor 1). Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 8C12.
UniProt Accession Number of Target Protein: P17927
Alternative Name(s) of Target: CR1 ; C3BR; C4BR; CD35; KN
Immunogen: Purified murine CR1 protein.
Specificity: Recognises an epitope on CD35 (CR1, 190 kDa), but not on CD21 (CR2, 145-150 kDa), which are alternative splice variants of primary Cr2 gene transcripts.
Application Notes: This antibody recognises murine CD35, expressed on the majority of peripheral B-cells and peritoneal macrophages and upon fMet-Leu-Phe stimulation also on
Antibody first published in:
Kinoshita et al. Monoclonal antibodies to mouse complement receptor type 1 (CR1). Their use in a distribution study showing that mouse erythrocytes and platelets are CR1-negative. J Immunol. 1988 May 1;140(9):3066-72 PMID:2966205
Note on publication:
Describes the generation and characterization of this antibody.
Immunohistochemical staining of rat stomach using anti-Complement receptor 1 antibody Ab00238-23.0 Formalin fixed rat stomach slices were were stained with Ab00238-23.0 at 3 µg/ml.