United Kingdom (UK)
Recombinant monoclonal antibody to Prion Protein. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 31C6.
UniProt Accession Number of Target Protein: P04156
Alternative Name(s) of Target: PrP; ASCR; CD-Antigen
Immunogen: Recombinant mouse scrapie-Prion protein residues 23-231 (rMoPrP23-231).
Specificity: Binds human PrP residues 143-149.
Application Notes: This is antibody recognises and binds to residues 143-149 of PrP. High Levels of PrP (Prion Protein) are found in the brain of humans and animals that are infected with transmissible spongiform encephalopathies such as Creutzfeld-Jakob disease (CJD), Gerstmann-Straussler disease in humans or bovine spongiform encephalopathy (BSE) in cattle.
Antibody first published in:
Kim et al. 2004 Antigenic characterization of an abnormal isoform of prion protein using a new diverse panel of monoclonal antibodies. Virology. 2004; 320(1):40-51 PMID:15003861
Note on publication:
Describes the generation of several monoclonal antibodies against PrP by immunising PrP gene-ablated mice with the pathogenic form of PrP