United Kingdom (UK)
Recombinant monoclonal antibody to Cocaine. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma GNC92H2.
Alternative Name(s) of Target: Benzoylmethylecgonine
Immunogen: Benzoylecgonine-KLH conjugate.
Specificity: Specifically binds to Benzoylmethylecgonine (Cocaine) with a Kd= 4E-7, which is 100-fold difference in Kd to the carboxylic acid metabolite Benzoylmethylecgonine
Application Notes: This antibody binds to cocaine, a strong stimulant used clinically as a local analgesic and vasoconstrictor, as well as illegally as a recreational drug.
Antibody first published in:
Larsen et al. 2001 Crystal Structure of a Cocaine-binding Antibody. Journal of Molecular Biology 2001; 311:9-15 PMID:11469854
Note on publication:
Describes the generation and humanisation of a cocaine-binding antibody and the determination of its crystal structure.