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- Ab00394-1.1 Anti-Metarhodopsin-I [K42-IL]
- Bovine
- Mouse IgG1
- Purified
- Ships in 5-6 weeks
- Ab00394-1.4 Anti-Metarhodopsin-I [K42-IL]
- Bovine
- Mouse IgG1
- Fc Silent™
- Purified
- Ships in 5-6 weeks
Recombinant monoclonal antibody to Metarhodopsin-I. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma K42-IL.
UniProt Accession Number of Target Protein: P02699
Immunogen: Bovine rod cell disc membranes.
Specificity: The antibody binds specifically to the C3-loop of metarhodpsin-I with a Kd of 2.8 nM, the epitope being TGALQERSK.
Application Notes: This antibody specifically binds to the C3-loop of metarhodopsin-I, which is in equilibrium with the meta-active metarhodopsin II. The antibody stabilises the inactive metarhodopsin-I, inhibiting G-protein activation.
Antibody first published in:
Adamus et al. Use of peptides to select for anti-rhodopsin antibodies with desired amino acid sequence specificities. Peptide Research 1988; 1(1):42-47 PMID:2485225
Note on publication:
Describes the generation of several monoclonal antibodies against rhodopsin using peptides for hybridoma selection.