United Kingdom (UK)
Recombinant monoclonal antibody to Human Creatine Kinase-MM. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma MAK33.
UniProt Accession Number of Target Protein: P06732
Alternative Name(s) of Target: CK-MM
Immunogen: Human creatine-kinase-MM in Al(OH)3.
Specificity: The antibody binds specifically to the human creatine-kinase-MM subtype (and not the the MB or BB subtype).
Application Notes: This antibody binds to human muscle creatine-kinase-MM, an enzyme that catalyzes the conversion of creatine and ATP to phosphocreatine and ADP, generating an ATP-buffer in the muscle. The antibody blocks CK-MM activity by 80%.
Antibody first published in:
Buckel et al. Cloning and nucleotide sequence of heavy- and light-chain cDNAs from a creatine-kinase specific monoclonal antibody Gene 1987; 51:13-19 PMID:3110009
Note on publication:
Describes the generation of a monoclonal antibody directed against the human creatine kinase M-subunit.