Anti-Insulin-degrading Enzyme [Fab-IDE]

Name: Anti-Insulin-degrading Enzyme [Fab-IDE]
SKU: Ab00406
Availability: InStock

Description:

Recombinant monoclonal antibody to Insulin-degrading Enzyme. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the scFv Fab-IDE.

Clone Name:

Fab-IDE

Published Application(s):

ELISA

Published Species Reactivity:

Human

Products based on this clone:

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Ab00406-1.1 Anti-Insulin-degrading Enzyme [Fab-IDE]
Human
Mouse IgG1
Purified
In Stock

Ab00406-10.0 Anti-Insulin-degrading Enzyme [Fab-IDE]
Human
Human IgG1
Purified
In Stock

Ab00406-10.3 Anti-Insulin-degrading Enzyme [Fab-IDE]
Human
Human IgG1
Fc Silent™
Purified
Ships in 4-5 weeks

Ab00406-10.7 Anti-Insulin-degrading Enzyme [Fab-IDE]
Human
Human F(ab)2
AbFab2™ His-Tagged
Purified
Ships in 4-5 weeks

UniProt Accession Number of Target Protein: P14735

Alternative Name(s) of Target: IDE; Insulin Protease
Immunogen: Human IDE.

Specificity: Binds specificially to human IDE with a Kd of 3.72 nM.

Application Notes: This antibody binds human insulin degrading enzyme, which breaks down insulin as well as amyloid peptides and is suggested to play a role in both diabetes and Alzheimer's. Antibody binding does not affect steady-state kinetics of IDE.

Antibody first published in: McCord et al. Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme. Proceedings of the National Academy of Sciences of the USA 2013; 110(34):13827-13832 PMID:23922390
Note on publication: Describes the generation of an antibody against human IDE and crystallisation of the complex.

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