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- Ab00408-1.1 Anti-TDRD3 [Fab-8-1]
- Human
- Mouse IgG1
- Purified
- In Stock
- Ab00408-1.4 Anti-TDRD3 [Fab-8-1]
- Human
- Mouse IgG1
- Fc Silent™
- Purified
- Ships in 4-5 weeks
- Ab00408-23.0 Anti-TDRD3 [Fab-8-1]
- Human
- Rabbit IgG
- Purified
- In Stock
Recombinant monoclonal antibody to TDRD3. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the scFv Fab-8-1.
UniProt Accession Number of Target Protein: Q9H7E2
Alternative Name(s) of Target: Tudor-domain-containing protein 3
Immunogen: Human TDRD3.
Specificity: Binds to human TDRD3 with a Kd-value of 1 nM. Specificity checked by ELISA - it show no binding to any of 13 non-cognate antigens.
Application Notes: This antibody binds to the tudor domain of TDRD3, a nuclear coactivator that recognizes and binds asymmetric dimethylation on the core histone tails associated with transcirptional activation such as H4R3me2 or H3R17me2. In the cytoplasm, it is suggested to be involved in the assembly and disassembly of mRNA stress granules. Interesting feature about this antibody: The CDR-H3 plays virtually no role in antigen recognition.
Antibody first published in:
Persson et al. Diversity is not required for antigen recognition by synthetic antibodies. Journal of Molecular Biology 2013; 425(4):803-811 PMID:23219464
Note on publication:
Describes the generation of several synthetic antibodies from phage display and subsequent crystallisation with TDRD3.