United Kingdom (UK)
Recombinant monoclonal antibody to 763.74. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma MK2-23.
Alternative Name(s) of Target: Ab763.74 idiotype; High molecular weight-associated melanoma antigen-neutralising antibody 763.74 (anti-idiotype)
Immunogen: Monoclonal antibody 763.74.
Application Notes: The antibody binds specifically to the monoclonal antibody 763.74. The 763.74 antibody has neutralising activity against HMW-MAA, a cell surface proteoglycan expressed on more than 90% of melanomas, which has been shown to contribute to the malignant transformation of cancer cells by inducing their invasion, growth and migration. The anti-idiotypic monoclonal antibody MK2-23 mimics HMW-MAA in the binding to 763.67, and can thereby increase the level of antibody production against the antigen in patients with the melanoma. This induces a humoral immune response which has caused the regression of melanomas in some patients and can prolong their survival.
Antibody first published in:
Kusama et al. Characterization of syngeneic anti idiotypic monoclonal antibodies to murine anti-human high molecular weight melanoma-associated antigen monoclonal antibodies. J Immunol. 1989 Dec 1;143(11):3844-52. PMID:2584721
Note on publication:
Describes the generation of the MK2-23 monoclonal antibody against human high molecular weight melanoma-associated antigen (HMW-MAA) using the standard hybridoma technology.