Anti-Plasma cell antigen 1 [4G6] Bulk size

Description: Recombinant monoclonal antibody to Plasma cell antigen 1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the scFv 4G6.
Isotype and Format: Mouse IgG1, kappa
Clone Number: 4G6
Published Application(s): ELISA; WB; IF; FC; IHC
Published Species Reactivity:
Immunogen: MRL-lpr/lpr T cells.
Specificity:
Application Notes: The antibody binds specifically to PC.1, an antigen which is highly expressed on the surface of plasma cells and some non-lymphoid tissue. The antigen is involved with secretion or exocytosis of immunoglobulins from B cells, and may play a role in the secretion of lymphokines from lpr/lpr T cells. When the population of this subset of T cells expands, it accumulates in lymph nodes and results lymphadenopathy. Studies have shown that preventing this expansion by performing neonatal thymectomy delays the onset of systemic lupus erythematosus (SLE), suggesting that the T cells play a role in the development of the autoimmune disease. Monoclonal antibodies directed against PC.1 can be useful in the diagnosis and monitoring of SLE.
Antibody First Published in:
Dumont FJ, Habbersett RC, Coker LZ, Nichols EA, Treffinger JA. Cell Immunol. 1985 Dec;96(2):327-37. PMID:2943419 Note on publication: Describes the generation of the xenogeneic monoclonal antibody 4G6, which reacts strongly with T cells of MRL-lpr/lpr mice that highly express PC.1. This indicates that the T cell subset involved in the development of systemic lupus erythematosus syndrome posses properties of B cells.

Product Form

This is a Bulk size product. Purified antibody in bulk size.
Purification: Protein A affinity purified
Supplied in: PBS only.
Storage Recommendation: Store at 4°C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20°C.
Concentration: See vial label

Product Code: Ab00507-1.1-BT

Mouse IgG1

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Standard size 200 µg
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