Anti-Plasma cell antigen 1 [4G6]

Description:

Recombinant monoclonal antibody to Plasma cell antigen 1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the scFv 4G6.

Clone Name:

4G6

Published Application(s):

WB, ELISA, FC, IF, IHC

Published Species Reactivity:

Mouse

Products based on this clone:

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Ab00507-1.1 Anti-Plasma cell antigen 1 [4G6]
Mouse
Mouse IgG1
Purified
In Stock

Ab00507-2.0 Anti-Plasma cell antigen 1 [4G6]
Mouse
Mouse IgG2a
Purified
In Stock

Ab00507-2.3 Anti-Plasma cell antigen 1 [4G6]
Mouse
Mouse IgG2a
Fc Silent™
Purified
Ships in 4-5 weeks

Ab00507-24.1 Anti-Plasma cell antigen 1 [4G6]
Mouse
Goat IgG
Purified
Ships in 4-5 weeks

Ab00507-23.0 Anti-Plasma cell antigen 1 [4G6]
Mouse
Rabbit IgG
Purified
In Stock

Alternative Name(s) of Target: PC.1
Immunogen: The original version of this antibody was raised by immunizing rats with MRL-lpr/lpr T cells.

Specificity: This antibody recognizes the plasma cell antigen 1.

Application Notes: The antibody binds specifically to PC.1, an antigen which is highly expressed on the surface of plasma cells and some non-lymphoid tissue. The antigen is involved with secretion or exocytosis of immunoglobulins from B cells, and may play a role in the secretion of lymphokines from lpr/lpr T cells. When the population of this subset of T cells expands, it accumulates in lymph nodes and results lymphadenopathy. Studies have shown that preventing this expansion by performing neonatal thymectomy delays the onset of systemic lupus erythematosus (SLE), suggesting that the T cells play a role in the development of the autoimmune disease. Monoclonal antibodies directed against PC.1 can be useful in the diagnosis and monitoring of SLE.

Antibody first published in: Dumont FJ, Habbersett RC, Coker LZ, Nichols EA, Treffinger JA. High level expression of the plasma cell antigen PC.1 on the T-cell subset expanding in MRL/MpJ-lpr/lpr mice: detection with a xenogeneic monoclonal antibody and alloantisera. Cell Immunol. 1985 Dec;96(2):327-37. PMID:2943419
Note on publication: Describes the generation of the xenogeneic monoclonal antibody 4G6, which reacts strongly with T cells of MRL-lpr/lpr mice that highly express PC.1. This indicates that the T cell subset involved in the development of systemic lupus erythematosus syndrome posses properties of B cells.

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