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- Ab00512-1.1 Anti-OA3 [OV-TL3]
- Human
- Mouse IgG1
- Purified
- Ships in 5-6 weeks
- Ab00512-10.0 Anti-OA3 [OV-TL3]
- Human
- Human IgG1
- Purified
- Ships in 5-6 weeks
Recombinant monoclonal antibody to OA3. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma OV-TL3.
Alternative Name(s) of Target: OA3 TA; Tumour-associated antigen OA3
Immunogen: Tumor cell suspension prepared from an ovarian endometrioid carcinoma.
Specificity: The antibody binds to OA3 with an affinity (Kd) of 0.71 nM.
Application Notes: The antibody binds specifically to OA3, a cell surface glycoprotein tumour-associated antigen with a multi membrane spanning structure. The antigen is expressed by the major histological types of ovarian carcinoma, and antibodies directed against the antigen can be used for both the diagnosis and treatment of primary and metastatic ovarian carcinomas.
Antibody first published in:
Poels LG, Peters D, van Megen Y, Vooijs GP, Verheyen RN, Willemen A, van Niekerk CC, Jap PH, Mungyer G, Kenemans P. Monoclonal antibody against human ovarian tumor-associated antigens. J Natl Cancer Inst. 1986 May;76(5):781-91. PMID:3517452
Note on publication:
Describes the generation of a monoclonal antibody raised against ovarian tumour-associated antigens, and the subsequent study of the reactivity of the clone.