Anti-17-Hydroxyprogesterone [101.B11.1] Bulk size

Description: Recombinant monoclonal antibody to 17-Hydroxyprogesterone. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 101.B11.1. This antibody was created using our proprietary Fc Silent™ engineered Fc domain containing key point mutations that abrogate binding to Fc gamma receptors.
Isotype and Format: Human IgG1, Fc Silent™, kappa
Clone Number: 101.B11.1
Published Application(s): ELISA; EIA
Published Species Reactivity:
Immunogen: Mouse 17-OHP.
Specificity: The antibody binds to 17-OHP with a Kd of 2.9 nM reported for the original antibody.
Application Notes: The antibody binds specifically to 17-OHP, an endogenous progestogen which acts as a chemical intermediate in the synthesis of steroid hormones such as corticosteroids, androgens and estrogens. 17-OHP levels are extremely high in patients who suffer from congenital adrenal hyperplasia (CAH), a disorder of the adrenal glands caused by the deficiency of 21-hydroxylase which catalyses the production of cortisol. This results in the accumulation of the cortisol precursors, and in particular of 17-OHP. Monoclonal antibodies that bind specifically to 17-OHP can therefore be used to measure 17-OHP levels in the diagnosis of CAH.
Antibody First Published in:
Sawada J, Terao T, Itoh S, Maeda M, Tsuji A, Hosoda H, Nambara T. J Steroid Biochem. 1987 Oct;28(4):405-10. PMID:3312820 Note on publication: Describes the production of hybridoma clones producing antibodies to 17-OHP and the establishment of cross-reactivity with other steroids. A micro-EIA system of 17-OHP using the monoclonal antibodies can be used for the mass-screening of congenital adrenal hyperplasia.

Product Form

This is a Bulk size product. Purified antibody in bulk size.
Purification: Protein A affinity purified
Supplied in: PBS only.
Storage Recommendation: Store at 4°C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20°C.
Concentration: See vial label

Product Code: Ab00526-10.3-BT

Human IgG1

Ships in 2-3 weeks
Standard size 200 µg
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