Anti-CD47 [OX-101]

Description:

Recombinant monoclonal antibody to CD47. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma OX-101.

Clone Name:

OX-101

Published Application(s):

IP, WB, Block, FC

Published Species Reactivity:

Rat

Product based on this clone:

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Ab00570-1.1 Anti-CD47 [OX-101]
Rat
Mouse IgG1
Purified
Ships in 4-5 weeks

UniProt Accession Number of Target Protein: P97829

Alternative Name(s) of Target: IAP; OX101; MRC OX-101; MRC OX101; leukocyte surface antigen CD47; integrin-associated protein; intergin associated protein
Immunogen: OX-101 was prepared by immunizing BALB/c mice with biotinylated rat thymocytes - this antibody was selected from a number of antibodies raised by the immunogen.

Specificity: OX-101 binds specifically to CD47 and has been shown to compete with OX-41 for binding . CD47 acts as an adhesionn receptor for THBS1 on platelets and is involved in the modulation of integrins (signalling). Acts as a SIRPA receptor - SIRPA binding prevents maturation of immature dentritic cells and and inhibits cytokine production by mature dendritic cells. Possibly involved in changes to membrane permeability due to virus infection.

Application Notes: This antibody can be used for affinity chromatography purification and can block the interaction between OX41-CD4d3+4 beads and cells. In addition OX-101 can be used for FC and WB.

Antibody first published in: Vernon-Wilson et al CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPalpha 1. Eur J Immunol 30:2130-7 2000 PMID:9712053
Note on publication: Describes the use of OX-101 in identifying CD47 as the ligand for SIRP.

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