United Kingdom (UK)
Recombinant monoclonal antibody to HPV16E6 & HPV18E6. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma C1P5.
Alternative Name(s) of Target: HPV early proteins; Human Papilloma Virus-16 and 18 early protein 6 HPV16E6 & HPV18E6;
Immunogen: Gel-purified HPV-18 E6-beta galactosidase fusion protein.
Specificity: This antibody binds to Human Papilloma Virus-16 and 18 early protein 6.
Application Notes: This antibody reacts with HPV infected human cells. The human papilloma virus (HPV) family of DNA tumor viruses, which includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. C1P5 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.
Antibody first published in:
Banks et al. Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas. J Gen Virol. 1987 May;68 ( Pt 5):1351-9. PMID:3033140
Note on publication:
This article describes the generation and characterisation of C1P5 antibody.