United Kingdom (UK)
Recombinant monoclonal antibody to IFN gamma. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody A4.
UniProt Accession Number of Target Protein: P01579
Alternative Name(s) of Target: IFNG; Interferon gamma; Immune interferon ; IFN-gamma
Immunogen: 2D-PAGE gel isolated human IFN gamma from lysate of human melanoma COLO-38 cells.
Specificity: This antibody binds to human Interferon gamma
Application Notes: The antibody binds specifically to IFN gamma, a dimerised soluble cytokine member of the type II class of interferons synthesised by activated T-lymphocytes and natural killer (NK) cells. . IFNγ plays a role in both the innate and adaptive immune responses, and is important in the activation of macrophages, induces the expression of MHC class I molecules, and has antiviral and immunoregulatory activities.
Antibody first published in:
Pini et al. Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel. J Biol Chem. 1998 Aug 21;273(34):21769-76. PMID:9705314
Note on publication:
Describes generation, using phage display, of antibodies with subnanomolar affinity against markers of angiogenesis.