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- Ab00675-2.0 Anti-NS1 [22NS1 ]
- West Nile Virus
- Mouse IgG2a
- Purified
- In Stock
- Ab00675-23.0 Anti-NS1 [22NS1 ]
- West Nile Virus
- Rabbit IgG
- Purified
- In Stock
Recombinant monoclonal antibody to NS1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 22NS1 .
Alternative Name(s) of Target: Flavivirus nonstructural protein 1; WNV NS1
Immunogen: A recombinant, secreted form of West Nile virus (WNV) NS1 glycoprotein from baculovirus-infected insect cells.
Specificity: This antibody binds to the NS1 protein (aa 158 to 352) of WNV lineage I (New York strain 3000.0259) and lineage II WNV (956). No reactivity to Dengue virus-2 (16681) was observed.
Application Notes: This antibody binds the NS1 protein and has a protective function in a C57BL/6 mouse-model . NS1 binds several complement proteins (C1q, C1s, and C4) and regulators (factor H, C4 binding protein, and clusterin)and antagonizes their functions
Antibody first published in:
Chung et al. Antibodies against West Nile Virus Nonstructural Protein NS1 Prevent Lethal Infection through Fc γ Receptor-Dependent and -Independent Mechanisms J Virol. 2006 Feb; 80(3): 1340–1351 PMID:16415011
Note on publication:
Describes the generation and characterization of protection of this antibody.