United Kingdom (UK)
Recombinant monoclonal antibody to JEV virions (E/PrM). Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody TJE12B02.
Alternative Name(s) of Target: Japanese Encephalitis virions; Envelope protein; PrM protein
Immunogen: Phage display library papanned 3 times on purified Japanese encephalitis virus (JEV) virions (Nakayama strain)
Specificity: This antibody bids to JEV virions. It is unclear whether this antibody binds to the E-protein or to PrM as an immunocomplex containing both is precipitated by this antibody.
Application Notes: This antibody binds to JEV virions and immunoprecipitates a complex containing E and PrM protein. In a Fab format, it showed neutralizing activity in an in vitro system using baby hamster kidney (BHK)-21 cells.
Antibody first published in:
Arakawa et al. Construction of human Fab (gamma1/kappa) library and identification of human monoclonal Fab possessing neutralizing potency against Japanese encephalitis virus. Microbiol Immunol. 2007;51(6):617-25. PMID:17579273
Note on publication:
Describes the generation as well as functional and structural characterization of this antibody.