United Kingdom (UK)
Recombinant monoclonal antibody to Der p 7. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma WH9.
UniProt Accession Number of Target Protein: P49273
Alternative Name(s) of Target: Mite allergen Der p 7; Allergen Der p VII; Major mite fecal allergen Der p 1; Dermatophagoides farinae allergen 1; Dermatophagoides pteronyssinus allergen 1
Immunogen: Recombinant Der p 7.
Specificity: This antibody binds to the house dust mite allergen Der p 7 and competes with a subset of naturally occurring IgE.
Application Notes: The antibody binds specifically to Der p 7, a house dust mite allergen which plays an important role in inflammatory and hypersensitive reactions. The antibody WH9 binds to an epitope which is overlapping with that of IgE, thereby inhibiting its binding by up to 60%. By preventing mast cell degranulation, the antibody can be useful in the development of hypoallergenic vaccines.
Antibody first published in:
Shen et al. Characterization of the house dust mite allergen Der p 7 by monoclonal antibodies. Clin Exp Allergy. 1995 May;25(5):416-22. PMID:7553244
Note on publication:
Describes the role of the house dust mite allergen Der p 7 in allergy, and the generation of monoclonal antibodies that target Der p 7.