United Kingdom (UK)
Recombinant monoclonal antibody to E2 B domain. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the humanized murine antibody 3b4c-4.
Alternative Name(s) of Target: VEEV envelope protein 2 domain B
Immunogen: This antibody was obtained by immunization of mice with TC-83 virus and was humanized using combinatorial antibody libraries and phage display technology.
Specificity: This antibody binds to the tip of the E2 B domain, between residues Ser182 and Ile207.
Application Notes: This antibody has been shown to have protective effects in VEEV challenge and has been used in crystallization studies as well as ELISA.
Antibody first published in:
Roehrig et al. Antigenic analysis of the surface glycoproteins of a Venezuelan equine encephalomyelitis virus (TC-83) using monoclonal antibodies. Virology. 1982 Apr 30;118(2):269-78. PMID:6178209
Note on publication:
Describes the generation of hybridoma secreting the original antibody.