Anti-ZIKV soluble envelope protein [z23]

Description:

Recombinant monoclonal antibody to ZIKV soluble envelope protein. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma z23.

Clone Name:

z23

Published Application(s):

Block

Published Species Reactivity:

Zika Virus

Products based on this clone:

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Ab00906-10.0 Anti-ZIKV soluble envelope protein [z23]
Zika Virus
Human IgG1
Purified
In Stock

Ab00906-10.3 Anti-ZIKV soluble envelope protein [z23]
Zika Virus
Human IgG1
Fc Silent™
Purified
Ships in 4-5 weeks

Ab00906-23.0 Anti-ZIKV soluble envelope protein [z23]
Zika Virus
Rabbit IgG
Purified
In Stock

Ab00906-13.12 Anti-ZIKV soluble envelope protein [z23]
Zika Virus
Human IgG4-S228P
Purified
Ships in 4-5 weeks

Alternative Name(s) of Target: sE; ZIKV
Immunogen: This antibody was derived from memory B cells specific for purified monomeric Zika virus soluble envelope protein, which were isolated by FACS from the blood of a patient 20 days post-infection with zika virus. To generate full-length monoclonal antibodies, the variable regions were then cloned into human IgG1 constant region.

Specificity: This antibody bind a tertiary epitope in the zika virus soluble envelope protein domain III.

Application Notes: This antibody specifically and potently neutralises Zika virus in vitro, and does not cross-react with strains 1 - 4 of dengue virus, which minimises the risk of antibody-dependent enhancement (Wang et al, 2016). In a murine model, this antibody confers postexposure protection against Zika virus (Wang et al, 2016).

Antibody first published in: Wang et al. Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Science Translational Medicine, December 14, 2016, Vol.8(369), p.369ra179 PMID:27974667
Note on publication: Describes the original generation and characterisation of this antibody.

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