Engineered Antibody Production

Absolute Antibody specializes in antibody engineering and the recombinant production of antibodies in any format. Our IgXpress™ antibody expression platform uses serum-free mammalian transient expression as a faster, more affordable alternative to stable cell line generation, and we’ve used it to manufacture antibodies in any species, isotype or subtype, as well as novel formats such as multispecifics, fragments and Fc fusion proteins. Our Periodic Table of Antibodies illustrates the more than 140 different antibody formats we’ve produced to date, with our real-world expression experience informing the manufacturability score of each antibody.

We can start antibody engineering and expression from your electronic antibody sequence, hybridoma cell line or purified antibody protein. We typically begin with a milligram-scale pilot production run to determine expression levels and purification strategy before moving onto larger-scale production. All production occurs at our ISO 9001:2015-certified manufacturing facility.

Depending on your needs, we can provide a reliable outsourcing solution for engineered antibody production, or a true consultative partnership in which we provide antibody engineering recommendations throughout the process to help optimize your antibody candidate. Either way, your project will be supported by a dedicated team with deep experience in therapeutic antibody development. All our services are royalty-free and customizable to your project.

View the 145 antibody formats we’ve manufactured to date.

Our engineered antibody production services include isotype switching, bispecific and trispecific antibodies, antibody fragments, and more. We use a variety of antibody purification strategies to enable manufacturing success across such a wide range of formats, including a proprietary lectin-based purification system for our IgA, IgM and IgE antibodies. Each engineered antibody is different, and our pilot run will inform further and larger-scale production to ensure we deliver antibodies of the highest possible quality.

To learn more, contact us or fill out the form below to start a discussion about your project.

We also offer standardized IgG antibody production, as well as a dedicated high-throughput antibody production service, if you have other antibody expression needs.

Contact Us About Your Antibody Expression Project

Fill out the form below to start a conversation about your antibody expression needs. A sales representative will be in touch shortly to discuss details, review pricing and answer any questions.
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