Comparing potential bispecific formats comprising of trastuzumab and a humanized OKT3

Multispecific antibodies with varying designs continue to enter the clinic, with a recent report stating that 79 multispecific antibodies encompassing 25 different designs are now clinically available. At Absolute Antibody, we have produced more than 180 different engineered antibody formats. In this case study, we have taken two well-studied monoclonal antibodies and we have shown that not all bispecific formats are created equal.

We systematically built and evaluated 17 bispecific designs, including a number of well-utilized formats. We found that Fc-containing formats and the placement of scFv can influence the expression dramatically, while interface stability for heterodimeric constructs is equally important.

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