Tumor antigens are proteins and carbohydrates produced by tumor cells that are expressed on the surface of the cell or released into the bloodstream. Tumor antigens can be tumor associated antigens, TAAs, which are relatively restricted to tumor cells, or tumor specific antigens, TSAs, which are unique to tumor cells. Tumor antigens serve as important tumor markers and can be used as targets in the detection and treatment of cancer. Antibodies targeting these tumor markers may have diagnostic applications in detection of the presence, type and stage of cancer. They also form an important class of therapeutic antibodies.
Absolute Antibody offers a wide range of anti-TAA/TSA antibodies. We have used our recombinant antibody technology and antibody engineering to generate different engineered formats of these antibodies for all your experimental needs. Recombinant production ensures batch-to-batch reproducibility, high purity and low endotoxin levels. These antibodies can be used to study antibody-dependent effector functions or to help develop antibody-drug conjugates for cancer treatment. Mouse and human isotypes with high effector functions are ideal for use in various in vitro and pre-clinical in vivo models. Our Fc Silent™ formats, help to eliminate antibody directed cytotoxicity (ADCC) effector function of Fc receptors.
We can further engineer these anti-TAA/TSA antibodies using our bispecific platform (e.g. anti-CD3, as well as other immune checkpoints and innate immune checkpoints like CD47) to create bispecific effector cell engagers or combine them with cell penetrating peptides to create antibodies that can penetrate the cell and target intracellular tumor antigens. We also provide a wide selection of mouse and human frameworks that can be used to engineer your antibodies. View all of our anti-TAA/TSA antibodies here.
To see all of the formats we have engineered and manufactured for our customers, check out our Periodic Table of Antibodies here. If you would like to discuss engineering our anti-TAA/TSA antibodies to fit your research needs, please contact us.
AACC Annual Meeting – Booth #3459
26-30th September 2021