We’re excited to launch our VivopureX™ recombinant mouse antibodies at bulk-discounted prices ideal for in vivo research. As Absolute Antibody continues to increase our production capacity and yield, we can more cost-effectively manufacture large quantities of antibody reagents and pass these savings along to our customers. The VivopureX™ antibody collection includes a selection of our most exciting mouse-anti-mouse antibodies, now available in bulk sizes ranging from 1 mg to 100 mg at significantly lower and highly competitive prices.
The VivopureX™ collection consists of popular antibody clones, many originally obtained from rats or hamsters, which Absolute Antibody has engineered into mouse-anti-mouse recombinant versions to improve research results. These species-matched chimeric antibodies consist of a clone’s original antigen-binding variable domain with a mouse constant domain.
Our VivopureX™ recombinant mouse antibodies offer many advantages compared to the original antibody format, including:
- Reduced immunogenicity: no neutralizing antibodies are induced in the host organism, meaning the antibody works for longer and cohorts respond more consistently.
- Tailored effector function: antibody formats have been engineered to suit their most popular application. (Increased Fc receptor binding increases depleting potential, while reduced Fc receptor binding reduces side effects in blocking.)
- Increased potency: less antibody is required to achieve the same response in mouse models.
- Batch-to-batch reproducibility: recombinant production ensures the highest possible reproducibility, while guaranteeing high purity and low endotoxin levels (<0.5 EU/mg).
Our data illustrate how VivopureX™ mouse antibodies provide increased long-term efficacy, potency and consistency compared to the original rat antibodies. In the figure to the left, our recombinant mouse PD-1 antibody based on the widely used clone RMP1-14 reduced tumor size in a mouse model more effectively than the original rat version. Download our research poster on the engineered PD-1 antibody to learn more.
You can view the full list of VivopureX™ antibodies and discounted bulk sizes here.
You can view the official announcement here.
Please join us at the following conferences and events. Stop by our booth, or get in touch to arrange a meeting.See All Dates
Antibody Engineering & Therapeutics Europe – Booth #25
6-8th June 2023