Anti-Virus Antibodies

In virology research, the pursuit of groundbreaking discoveries hinges on the precision and reliability of antibody research tools. High-quality antibodies play a pivotal role in unraveling the intricacies of viral biology, aiding scientists in virus identification, pathway and neutralization studies, and vaccine development. The need for antibodies with exceptional specificity and sensitivity is paramount to accurately discern virus-host interactions. Our recombinant engineered antibodies empower virology researchers by providing tools that meet the demands of today’s scientific inquiries.

Recombinant Engineered Antibodies for Virus Research

Our virology antibody collection includes antibodies for dengue (and other flaviviruses), VSV, influenza, HIV, hepatitis, and more, offering precise tools for comprehensive research. Our antibodies are versatile, enabling studies on viral entry, replication mechanisms, and host-virus interactions. Recombinantly engineered with features like Fc Silencing for minimal background interference, our antibodies ensure accuracy in experimental outcomes. With a range of species, isotypes, and subtypes available off the shelf, including human IgG, IgM, and IgA, along with conjugation options and customizable services, we cater to diverse virology research needs, providing specificity and sensitivity for investigations into viral pathogenesis and dynamics.

Featured Targets

Anti-Flavivirus group antigen [D1-4G2-4-15 (4G2)]

Detection of Zika virus by immunofluorescence.

Anti-COVID-19 & SARS-CoV S glycoprotein [CR3022]

Binding curve of anti-COVID-19 & SARS-CoV S glycoprotein antibody CR3022 (Ab01680-10.0) to SARS-CoV-2 Spike Glycoprotein (S1), Sheep Fc-Tag and SARS-CoV-2 Spike Glycoprotein (S2), Sheep Fc-Tag from HEK293 cells.

Anti-dsRNA [9D5]

Immunofluorescence staining of cells infected with a Dengue 2 virus.

SARS-CoV-2 Antibodies

To facilitate COVID-19 research, we offer antibodies for SARS-CoV-2 detection, like the highly cited anti-SARS-CoV S glycoprotein antibody clone CR3022. Our proprietary recombinant production platform ensures 100% biological definition, batch-to-batch reproducibility, and opens our antibodies to engineering opportunities like species switching and multispecific varieties. Our CR3022 clone is available in multiple species (human, mouse, rabbit, cat, and ferret) and isotypes. Additionally, we engineered this clone into Fab fragments and F(ab)2 variations for even more experimental possibilities.

We also bundled our recombinant-engineered SARS-CoV-2 antibodies with polyclonal goat anti-SARS-CoV-2 S protein antibodies from our sister brand, Everest Biotech, to create the perfect COVID antibody matched pair for ELISAs. With a polyclonal capture antibody and a recombinant detection antibody, researchers can benefit from the affordable reliability of goat polyclonal antibodies as their capture antibody and the specificity and clean data of recombinantly engineered antibodies for detection.

Anti-dsRNA Antibodies

We also offer recombinant engineered antibodies against double-stranded RNA (dsRNA), a critical element in the realm of virus research and one of the preeminent viral detection and discovery methods. These antibodies are specifically designed to provide researchers with unparalleled precision and reliability, unlocking new avenues for viral load detection and understanding viral dynamics. Our dsRNA antibodies are available in a variety of species, isotypes, and with options for abrogated Fc binding for expanded experimental opportunities.

Among our offerings, we feature engineered versions of the highly cited SCICONS anti-dsRNA antibody clone J2, which is often used to detect dsRNA intermediates of a wide range of viruses in cells and tissues, for applications including IHC, IF, Western blot, ELISA and electron microscopy. For more information on SCICONS antibodies, view the entire product range through our sister brand Exalpha.

Immunofluorescence staining of Zika virus-infected A549 cells with anti-dsRNA antibody J2 (Ab01299).

Other Targets

HIV Antibodies: Recombinant engineered HIV antibodies empower researchers to delve into the virus’s complex life cycle, aiding in the study of viral entry, replication, and immune evasion. Particularly, our broadly-neutralizing HIV-1 antibodies provide a unique toolset to study diverse viral strains, potentially paving the way for advancements in HIV research.
Hepatitis Antibodies: Our range of recombinant engineered antibodies for hepatitis research plays a pivotal role in deciphering the molecular mechanisms underlying hepatitis infections. These antibodies target key viral components like the HBV surface antigen in the case of our anti-HBsAg [5C3] antibody, available in mouse, rabbit, and human formats.
Zika Antibodies: Our products empower Zika virus research. Designed to target crucial Zika viral proteins, these antibodies aid researchers in unraveling the virus’s pathogenesis, neurotropism, and potential links to birth defects. By providing specific tools for Zika research, like our Anti-Envelope protein [ZKA64] antibody, antibodies contribute to a more comprehensive understanding of this emerging viral threat.
FHV Antibodies: Our recombinant engineered antibodies for Feline Herpesvirus (FHV) research facilitate investigations into viral replication, host immune responses, and potential antiviral strategies, empowering researchers to uncover critical insights into the virus’s biology and contribute to advancements in veterinary virology. Our Anti-FHV-1 [JH2] recombinant antibody can be used for cat diagnostics, therapeutics, and virus neutralization.
And More! Our catalog includes a wide range of other anti-virus antibodies, including Anti-VSV-M [23H12], Anti-RRV E2 [D7], Anti-influenza [2-12C], and Anti-DI/DII domain of Dengue E protein [DV78].

Anti-Virus Antibodies Resources

Application Note

Transient Antibody Expression Platform Drives Batch-to-Batch Reproducibility for COVID-19 Diagnostic Assay

Our assessment of batch-to-batch reproducibility for the CR3022 anti-coronavirus spike glycoprotein antibody, widely utilized in COVID-19 diagnostic assays, demonstrates consistent stability and minimal variability, affirming the reliability of the recombinant protein for interchangeable use in calibrating or evaluating the performance of serology tests for anti-SARS-CoV-2 antibodies.

Case Studies

Engineering ACE2 Fc Fusion Proteins For COVID-19 Prophylaxis

Absolute Antibody collaborated with Paradigm Immunotherapeutics to engineer their high-affinity ACE2 Fc fusion proteins effective against all coronavirus variants into versions with Fc silencing and extended half-life for enhanced efficacy and safety in humans.

Large-Scale Production of the First Pig Influenza Antibodies

Absolute Antibody contributed to the Pirbright Institute’s pioneering work on the first-ever pig antibodies against influenza by recombinantly expressing and manufacturing a top antibody candidate, supporting advancements in influenza research and potential applications in therapeutics and vaccines.

Engineered, Species-Matched Antibody Allowed for Long-Term CD8+ T-Cell Depletion in Mice

In a collaborative effort with Prof. Daniel Pinschewer at the University of Basel, Absolute Antibody helped address challenges in long-term CD8+ T-cell depletion caused by chronic viral infections (as in the case of HIV and hepatitis infections) by providing our engineered anti-CD8 antibody, showcasing its in vivo efficacy.

Using Bispecific Antibody Reagents to Further Immunotherapy Research

Researchers at the Leiden University Medical Center (LUMC) worked with Absolute Antibody to develop T-cell-engaging CD3ε-bispecific antibodies that, when applied in conjunction with oncolytic reoviruses, caused tumor cell death in live mouse models.

Blog Posts

Our blog articles outline additional virus research antibodies available and how they contribute to moving the study of these ubiquitous biological entities forward.

Empowering Virus Research

In virology, high-quality antibodies against viruses aid in identification, neutralization studies, and vaccine development. Our cutting-edge recombinant antibodies meet the rigorous demands of today’s scientific inquiries, empowering researchers with even more experimental possibilities. Explore our table of anti-virus products below. If our antibody catalog lacks the tool you need, explore our custom engineering services. For quotes or other inquiries, please reach out.

Additionally, as an Absolute Biotech brand, we are proud to work with our other sister brands at the forefront of making research tools broadly available. LSBio provides a wide range of virus antibodies, proteins, ELISA kits, assay kits, and chemical compounds used by researchers to study and develop diagnostics and therapeutics for major viral diseases. With products against coronaviruses, hepatitis viruses, herpesviruses, influenza viruses, and more, LSBio’s catalog spans some of the most clinically relevant viral targets.

Kerafast’s Delta-G-VSV Pseudotyping System is another application of viruses for research. Using a vesicular stomatitis virus with the glycoprotein deleted (rVSV-ΔG), rVSV-ΔG allows researchers to insert genes of their choice to study the mechanisms of other viruses without the risks associated with dangerous pathogens. rVSV-ΔG can be implemented with just biosafety level 2 containment. Since it was first published in 2010, the Delta-G-VSV Pseudotyping System has been used worldwide for identifying cellular receptors for viruses, screening for entry inhibitors, and evaluating neutralizing antibody responses following vaccination.

Visit AbsoluteBiotech.com for more antibodies, reagents, and services.

Virology Research Antibodies

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