Anti-CCL2/CCL12 [11k2]

Name: Anti-CCL2/CCL12 [11k2]
SKU: Ab00344
Availability: InStock

Description:

Recombinant monoclonal antibody to CCL2/CCL12. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 11k2.

Clone Name:

11k2

Published Application(s):

Block, ELISA

Published Species Reactivity:

Human, Mouse

Products based on this clone:

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Ab00344-1.1 Anti-CCL2/CCL12 [11k2]
Human, Mouse
Mouse IgG1
Purified
In Stock

Ab00344-1.4 Anti-CCL2/CCL12 [11k2]
Human, Mouse
Mouse IgG1
Fc Silent™
Purified
In Stock

Ab00344-10.3 Anti-CCL2/CCL12 [11k2]
Human, Mouse
Human IgG1
Fc Silent™
Purified
In Stock

Ab00344-10.7 Anti-CCL2/CCL12 [11k2]
Human, Mouse
Human F(ab)2
AbFab2™ His-Tagged
Purified
Ships in 4-5 weeks

Alternative Name(s) of Target: cytokine A2, MCP-1, Monocyte chemotactic factor 1, MCP-5, CCL12
Immunogen: Human MCP-1.

Specificity: Binds to human CCL2.

Application Notes: This antibody binds to human CCL2, a small cytokine that recruits monocytes, memory T cells and dendritic cells to the sites of inflammation. Can block monocyte chemotaxis in cell migration assays (PMID: 15967845)

Antibody first published in: Lutgens E, Faber B, Schapira K, Evelo CT, van Haaften R, Heeneman S, Cleutjens KB, Bijnens AP, Beckers L, Porter JG, Mackay CR, Rennert P, Bailly V, Jarpe M, Dolinski B, Koteliansky V, de Fougerolles T, Daemen MJ. Gene Profiling in Atherosclerosis Reveals a Key Role for Small Inducible Cytokines Circulation. 2005 Jun 28;111(25):3443-52. Epub 2005 Jun 20. PMID:15967845
Note on publication: Describes time-related expression patterns in atherosclerosis and validation of the role of Mcps by generating and using the antibody 11k2.

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