United Kingdom (UK)
Recombinant monoclonal antibody to IL-5. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 2B6.
UniProt Accession Number of Target Protein: C9JQP9
Alternative Name(s) of Target: interleukin 5; IL5; IL 5; Eosinophil differentiation factor
Immunogen: This antibody was raised by immunising CAF1 mice with human recombinant IL-5.
Specificity: This antibody is specific for human rIL-5, and does not cross-react with human rIL-1α, rIL-lβ, rIL-4, rIL-8, rM-CSF, or rTGF-α.
Application Notes: This antibody has been show to inhibit the binding of human rIL-5 to the alpha chain of the IL-5 receptor (Ames et al, 1995). This antibody inhibits the proliferation of murine B13 cells in response to human IL-5 (Ames et al, 1995).Neutralising antibodies against IL-5 represent a potential therapeutic strategy for the treatment of eosinophilia. The specificity of this antibody for human IL-5 has been confirmed in ELISA analysis (Ames et al, 1995).
Antibody first published in:
Ames et al. Neutralizing murine monoclonal antibodies to human IL-5 isolated from hybridomas and a filamentous phage Fab display library. J. Immunol. 154 (12), 6355-6364 (1995) PMID:7759873
Note on publication:
Describes the original generation of this antibody, and its characterisation and use in ELISA.