United Kingdom (UK)
Recombinant monoclonal antibody to Myosin. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 14G2-B12.
Alternative Name(s) of Target: Q02566; Q91Z83; Q61879; Q6URW6; O08638; P13542; P13541; P97434; A2AQP0; Q02566
Immunogen: This antibody was raised by immunising a BALB/c mouse with cardiac myosin prepared from BALB/c mouse hearts.
Specificity: This antibody is specific for MF1, a fragment spanning amino acids 1 - 562 in the S1 domain of the head region of murine cardiac myosin. This antibody cross-reacts with keratin and GlcNAc-BSA.
Application Notes: The reactivity of this antibody with mouse cardiac myosin and GlcNAc-BSA has been confirmed in ELISA analysis (Malkiel et al, 2000). The affinity of this antibody for myosin is higher than its affinity for GlcNAc-BSA (Malkiel et al, 2000).
Antibody first published in:
Malkiel et al. T-Cell-Dependent Antibody Response to the Dominant Epitope of Streptococcal Polysaccharide, N-Acetyl-Glucosamine, Is Cross-Reactive with Cardiac Myosin Infect. Immun. October 2000vol. 68 no. 10 5803-5808 PMID:10992488
Note on publication:
Describes the original generation of this antibody, and characterisation of its reactivity in ELISA analysis.