United Kingdom (UK)
Recombinant monoclonal antibody to Tetanus toxin. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma G6.
UniProt Accession Number of Target Protein: P04958
Alternative Name(s) of Target: STeNT; pasmogenic toxin; Tentoxylysin
Immunogen: Peripheral lymphocytes from humans hyperimmunized with tetanus toxoid were fused with a mouse/human heteromyeloma.
Specificity: G6 recognises the middle domain of the Tetanus toxin.
Application Notes: G6 has a neutralising activity of 1.4 IU/100 μg IgG (Kamei et al, 1990). From ELISA the Ka of G6 for tetanus toxin was determined as 10 x 10^10 M^1 (Matsuda et al, 1992).
Antibody first published in:
Kamei et al, 1990. Establishment of stable mouse/human-human hybrid cell lines producing large amounts of anti-tetanus human monoclonal antibodies with high neutralizing activity Eur J Epidemiol. 1990 Dec;6(4):386-97. PMID:2091939
Note on publication:
Describes the original production of the antibody.