Anti-17ß estradiol [10G6D6]

Description:

Recombinant monoclonal antibody to 17ß estradiol. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 10G6D6.

Clone Name:

10G6D6

Published Application(s):

IP, RIA, WB, ELISA

Published Species Reactivity:

Species independent

5

Products based on this clone:

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Ab00478-1.1 Anti-17ß estradiol [10G6D6]
Species independent
Mouse IgG1
Purified
In Stock

Ab00478-10.0 Anti-17ß estradiol [10G6D6]
Species independent
Human IgG1
Purified
In Stock

Ab00478-10.6 Anti-17ß estradiol [10G6D6]
Species independent
Human Fab fragment
His-Tagged
Purified
In Stock

Ab00478-10.7 Anti-17ß estradiol [10G6D6]
Species independent
Human F(ab)2
AbFab2™ His-Tagged
Purified
In Stock

Ab00478-23.0 Anti-17ß estradiol [10G6D6]
Species independent
Rabbit IgG
Purified
In Stock

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Alternative Name(s) of Target: 17-beta-estradiol; E2; ethynyl estradiol; oestradiol
Immunogen: estradiol-6-ethyl methoxy carbonyl (EMC)–bovine serum albumin (BSA).

Specificity: This antibody binds specifically to 17β estradiol, a mammalian estrogenic steroid hormone that is produced in the ovaries, placenta, and testis.

Application Notes: This antibody binds 17ß estradiol with a sensitivity of 33 ± 9 pg/ml. In women, 17β estradiol plays an important role in the development of secondary sexual characteristics and the maturation of long bones. It is also responsible for the activation of certain oncogenes and can be involved in the development of breast cancer and cancer of the uterine lining. Anti-estradiol antibodies can be useful in the detection of hormone concentrations in serum samples. This can be used therapeutically to monitor follicular maturation in cases of female infertility and estradiol-secreting tumors.

Antibody first published in: Bettsworth F, Monnet C, Watelet B, Battail-Poirot N, Gilquin B, Jolivet M, Menez A, Arnaud M, Ducancel F. Functional characterization of two anti-estradiol antibodies as deduced from modelling and site-directed mutagenesis experiments. J Mol Recognit. 2001 Mar-Apr;14(2):99-109. PMID:11301480
Note on publication: Describes the role of monoclonal antibodies in measuring concentrations of steroid hormones in human serum samples, and the characterization of two anti-estradiol monoclonal antibodies for this use.