Anti-2,3-dinor-6-keto-prostaglandin F1α [mAb6kPGF]

Description:

Recombinant monoclonal antibody to 2,3-dinor-6-keto-prostaglandin F1α. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma mAb6kPGF.

Clone Name:

mAb6kPGF

Published Application(s):

RIA, ELISA

Published Species Reactivity:

Human

5

Products based on this clone:

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Ab00482-1.1 Anti-2,3-dinor-6-keto-prostaglandin F1α [mAb6kPGF]
Human
Mouse IgG1
Purified
Ships in 4-5 weeks

Ab00482-10.0 Anti-2,3-dinor-6-keto-prostaglandin F1α [mAb6kPGF]
Human
Human IgG1
Purified
Ships in 4-5 weeks

Ab00482-10.6 Anti-2,3-dinor-6-keto-prostaglandin F1α [mAb6kPGF]
Human
Human Fab fragment
His-Tagged
Purified
In Stock

Ab00482-10.7 Anti-2,3-dinor-6-keto-prostaglandin F1α [mAb6kPGF]
Human
Human F(ab)2
AbFab2™ His-Tagged
Purified
In Stock

Ab00482-23.0 Anti-2,3-dinor-6-keto-prostaglandin F1α [mAb6kPGF]
Human
Rabbit IgG
Purified
Ships in 4-5 weeks

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Alternative Name(s) of Target: 2,3-dinor-6-keto-prostaglandin F1-alpha
Immunogen: Human 2,3-dinor-6-keto PGF1α.

Specificity: The antibody binds to to 2,3-Dinor-6-keto-prostaglandin F1α with an IC50 of 2.2 pmol and an affinity (Kd) of 2.22 nM.

Application Notes: The antibody binds specifically to 2,3-Dinor-6-keto-prostaglandin F1α, a major urinary metabolite of PGI2 (prostacyclin). PG12 is a product of cyclooxygenase, and acts as a potent vasodilator and inhibitor of platelet aggregation. 2,3-Dinor-6-keto-prostaglandin F1α is a stable urinary metabolite of PGI2, and its levels in the urine can be measured using monoclonal antibodies in immunoassays, giving an indication of the levels of PGI2 produced in the body.

Antibody first published in: Hiramatsu M, Hayashi Y, Yamamoto S, Hayashi A, Sawada M, Hamanaka N, Yamashita K. Application of an alpha-side chain length-specific monoclonal antibody to immunoaffinity purification and enzyme immunoassay of 2,3-dinor-6-keto-prostaglandin F1α from human urine. Prostaglandins Leukot Essent Fatty Acids. 1994 Feb;50(2):69-79. PMID:8171070
Note on publication: Describes the preparation of a monoclonal antibody by immunising a mouse with 2,3-dinor-6-keto-prostaglandin F1α conjugated to bovine serum albumin, and its use for the detection of PG12 in human urine.