United Kingdom (UK)
Recombinant monoclonal antibody to CCHFV NP protein. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the synthetic clone cAb4729 .
UniProt Accession Number of Target Protein: P89522
Alternative Name(s) of Target: CCHFV N proten; CCHFV nuceloprotein; Nucleocapsid protein; Protein N; Crimean Congo Haemorrhagic fever virus; cAb4729–10.0
Immunogen: The antibody 3G5 was generated by immunizing BALB/c mice with recombinant CCHFV protein. The CDRs of the parental mouse antibody 3G5 were grafted onto human framework regions to generate this humanized antibody.
Specificity: This antibody binds CCHFV. Crimean-Congo Haemorrhagic Fever virus (CCHFV) is a tick-borne pathogen belonging to the genus Orthonairovirus of the family Nairoviridae within the order Bunyavirales that is responsible for the disease Crimean-Congo haemorrhagic fever (CCHF). CCHF is a zoonotic disease typically spread by tick bites or close contact with the blood, secretions, organs or other bodily fluids of infected persons or animals. The CCHF virus causes severe viral haemorrhagic fever outbreaks, with a case fatality rate of 10–40%.
Application Notes: The antibody was capable of detecting the recombinant CCHFV nuceloprotein in an ELISA (PMID: 36496007).
Antibody first published in:
Dowall et al. Development of humanised antibodies for Crimean-Congo Haemorrhagic fever virus: Comparison of hybridoma-based versus phage library techniques. J Immunol Methods. 2023 Jan;512:113405. PMID:36496007
Note on publication:
Describes the generation of