Anti-CD11a [hu1124 (Efalizumab)]

Description:

Recombinant monoclonal antibody to CD11a. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the therapeutic antibody hu1124 (Efalizumab).

Clone Name:

hu1124 (Efalizumab)

Published Application(s):

Block, FC

Published Species Reactivity:

Human

6

Products based on this clone:

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Ab00535-10.0 Anti-CD11a [hu1124 (Efalizumab)]
Human
Human IgG1
Purified
In Stock

Ab00535-10.6 Anti-CD11a [hu1124 (Efalizumab)]
Human
Human Fab fragment
His-Tagged
Purified
Ships in 4-5 weeks

Ab00535-1.1 Anti-CD11a [hu1124 (Efalizumab)]
Human
Mouse IgG1
Purified
In Stock

Ab00535-23.0 Anti-CD11a [hu1124 (Efalizumab)]
Human
Rabbit IgG
Purified
In Stock

Ab00535-10.3 Anti-CD11a [hu1124 (Efalizumab)]
Human
Human IgG1
Fc Silent™
Purified
In Stock

Ab00535-2.0 Anti-CD11a [hu1124 (Efalizumab)]
Human
Mouse IgG2a
Purified
Ships in 4-5 weeks

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UniProt Accession Number of Target Protein: P20701

Alternative Name(s) of Target: LFA-1; integrin alpha L
Immunogen: Efalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes.

Specificity: Binds to human LFA-1.

Application Notes: Efalizumab binds to the LFA-1 alpha I domain blocking the ICAM-1 binding site via steric hindrance.

Antibody first published in: Bauer et al. Population pharmacokinetics and pharmacodynamics of the anti-CD11a antibody hu1124 in human subjects with psoriasis. J Pharmacokinet Biopharm. 1999 Aug;27(4):397-420. PMID:10826130
Note on publication: Describes the analysis of the pharmacokinetics and pharmacodynamics of hu1124 [Efalizumab].

Binding Curve

IHC on rat spleen tissue using Ab00535-10.0. Click on image for more details.

Binding Curve

Immunohistochemical staining of rat spleen tissue using anti-CD11a antibody (Ab00535) hu1124 (Efalizumab). Anti-CD11a staining of formaldehyde fixed paraffin embedded rat spleen tissue, at 40x magnification. The human IgG1-chimeric version of hu1124 (Ab00535-10.0) was used to stain samples at a concentration of 3 µg/ml.

Binding Curve

Flow-cytometry on human lymphocytes using Ab00535. Click on image for more details.

Binding Curve

Flow-cytometry using the anti-CD11a research biosimilar antibody Efalizumab (hu1124, Ab00535) Human lymphocytes were stained with an isotype control (Ab00102-23.0, panel A) or the rabbit-chimeric version of Efalizumab (Ab00535-23.0, panel B) at a concentration of 1 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a AF488 conjugated donkey anti-rabbit antibody (ab150073) and cells analysed on a FACSCanto flow-cytometer.

Binding Curve

IHC on rat spleen tissue using Ab00535-10.0. Click on image for more details.

Binding Curve

Immunohistochemical staining of rat spleen tissue using anti-CD11a antibody (Ab00535) hu1124 (Efalizumab). Anti-CD11a staining of formaldehyde fixed paraffin embedded rat spleen tissue, at 40x magnification. The human IgG1-chimeric version of hu1124 (Ab00535-10.0) was used to stain samples at a concentration of 3 µg/ml.