Anti-CD155 [scFv3]

Description:

Recombinant monoclonal antibody to CD155. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody scFv3.

Clone Name:

scFv3

Published Application(s):

functional assay

Published Species Reactivity:

Human

Products based on this clone:

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Ab03903-23.0 Anti-CD155 [scFv3]
Human
Rabbit IgG
Purified
Ships in 5-6 weeks

Ab03903-3.3 Anti-CD155 [scFv3]
Human
Mouse IgG2b
Fc Silent™
Purified
Ships in 5-6 weeks

Ab03903-3.0 Anti-CD155 [scFv3]
Human
Mouse IgG2b
Purified
Ships in 5-6 weeks

Ab03903-10.0 Anti-CD155 [scFv3]
Human
Human IgG1
Purified
Ships in 5-6 weeks

Ab03903-10.3 Anti-CD155 [scFv3]
Human
Human IgG1
Fc Silent™
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: P15151

Alternative Name(s) of Target: PVR; PVS; NECL-5; Poliovirus receptor; Nectin-like protein 5
Immunogen: The original antibody was isolated from an scFv phage display library generated by immunizing two BALB/c mice intradermally with paraformaldehyde fixed HT1080 cells (human fibrosarcoma cell line).

Specificity: This antibody binds human CD155 also called the poliovirus receptor (PVR). This protein mediates NK cell adhesion and triggers NK cell function. It also binds two NK cell receptors CD96 and CD226. CD155 is gaining more interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions.

Application Notes: This antibody show inhibitory effect on the invasion of HT1080 cells, MDA-MD231 cells in a chemotaxis assay with a Matrigel coated cell migration chamber. This antibody also has inhibitory effect on the migration of two different glioblastoma cell lines U87MG and A172 (US20090215175).

Antibody first published in: PMID: