- Ab00539-10.0 Anti-CD6 [OX-126]
- Human IgG1
- In Stock
- Ab00539-23.0 Anti-CD6 [OX-126]
- Rabbit IgG
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- Ab00539-1.1 Anti-CD6 [OX-126]
- Mouse IgG1
- In Stock
Recombinant monoclonal antibody to CD6. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma OX-126.
UniProt Accession Number of Target Protein: P30203
Alternative Name(s) of Target: TP120; OX126; MRC OX-126; MRC OX 126
Immunogen: This antibody was prepared by immunizing BALB/c mice with a fusion protein consisting of human CD6 domain 3 and rat CD4 domains 3 and 4.
Specificity: This antibody is specific for the ligand-binding domain of human CD6 (domain 3).
Application Notes: This antibody can block the interaction between CD6 and its ligand CD166, with a consequent reduction in antigen-specific IL-2 production by human T cells (Hassan et al, 2006).
Antibody first published in:
Hassan et al. CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76 MOLECULAR AND CELLULAR BIOLOGY, Sept. 2006, p. 6727–6738 PMID:16914752
Note on publication: Describes the original use of this antibody to engage human CD6, blocking the CD6/CD166 interaction.